Iodoethane → dimethyl N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-alpha-(ethylamino)ethylphosphonate

HRID 1953780노트

반응식

HRID 1953780 반응식
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([N:8]=[C:9]([O:16][CH3:17])[C:10]([O:14][CH3:15])=[N:11]2)=[C:6]([CH2:18][NH:19][CH:20]([P:22](=[O:27])([O:25][CH3:26])[O:23][CH3:24])[CH3:21])[CH:5]=1)([O-:3])=[O:2].[CH2:28](I)[CH3:29].C(N(C(C)C)CC)(C)C>C(#N)C>[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([N:8]=[C:9]([O:16][CH3:17])[C:10]([O:14][CH3:15])=[N:11]2)=[C:6]([CH2:18][N:19]([CH2:28][CH3:29])[CH:20]([P:22](=[O:27])([O:23][CH3:24])[O:25][CH3:26])[CH3:21])[CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 81531DiisopropylethylamineHCID 23297975Dimethyl N-(7-Nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-alpha-aminoethylphosphonate

생성물 1

HCID 23298022dimethyl N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-alpha-(ethylamino)ethylphosphonate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

300 mg (0.75 mmol) of dimethyl N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-α-aminoethylphosphonate, 0.482 ml (8 eq.) of ethyl iodide and 1.4 ml (11 eq.) of diisopropylethylamine are stirred at 700 for 24 hours in 10 ml of acetonitrile. The reaction mixture is evaporated and the residue is stirred in diethyl ether. The solid is filtered off, washed with diethyl ether and the filtrate is evaporated. The title compound is obtained as a brownish oil.

후처리

  1. customThe reaction mixture is evaporated
  2. filtrationThe solid is filtered off
  3. washwashed with diethyl ether
  4. customthe filtrate is evaporated

출처 및 근거

ORD 기록
ord-a2966ee69d99414abdb20a20e52a4394
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06117873

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