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Hydrochloric Acid → 2-[4-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl-methyl)phenyl]-2-cyclopentylacetic acid

HRID 1955740
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반응식

HRID 1955740 반응식
[BH4-].[Na+].[CH2:3]([C:7]1[N:8]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH:22]([CH:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)[C:23]([OH:25])=[O:24])=[CH:18][CH:17]=2)[C:9]([CH:13]=[O:14])=[C:10]([Cl:12])[N:11]=1)[CH2:4][CH2:5][CH3:6].Cl>C(O)C>[CH2:3]([C:7]1[N:8]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([CH:22]([CH:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[C:23]([OH:25])=[O:24])=[CH:20][CH:21]=2)[C:9]([CH2:13][OH:14])=[C:10]([Cl:12])[N:11]=1)[CH2:4][CH2:5][CH3:6]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 152255902-[4-(2-Butyl-4-chloro-5-formyl-imidazol-1-yl-methyl)-phenyl]-2-cyclopentylacetic acid

생성물 1

HCID 190725392-[4-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl-methyl)phenyl]-2-cyclopentylacetic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

0.1 g (2.9 mmol) of sodium borohydride is added to 1.5 g (2.9 mmol) of the compound from Example V in 25 ml of ethanol. After 1 h at room temperature, the reaction mixture is acidified (pH 4) with 2N HCl and extracted three times with CH2Cl2. The organic phase is dried over Na2SO4 and concentrated, and the product is crystallised from ethyl acetate/petroleum ether. A 1:1 mixture of the diastereomers is obtained.

후처리

  1. extractionextracted three times with CH2Cl2
  2. dry with materialThe organic phase is dried over Na2SO4
  3. concentrationconcentrated
  4. customthe product is crystallised from ethyl acetate/petroleum ether
  5. additionA 1:1 mixture of the diastereomers
  6. customis obtained

출처 및 근거

ORD 기록
ord-048a276b26194373a82a2426bb4f2161
출처 데이터셋
uspto-grants-1998_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05776964

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