Ethylenediamine → Ethyl 2-fluorocyclopropanecarboxylate

HRID 1956832

반응식

HRID 1956832 반응식
Cl[C:2]1([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:4][CH:3]1[F:5].NCCN>[Ni].C(O)C>[F:5][CH:3]1[CH2:4][CH:2]1[C:6]([O:8][CH2:9][CH3:10])=[O:7]

참가 물질

5

반응물 2

HCID 3301EthylenediamineHCID 15346054Ethyl 1-chloro-2-fluorocyclopropanecarboxylate

생성물 1

HCID 10313150Ethyl 2-fluorocyclopropanecarboxylate수율 81%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

An internal glass tube was introduced into an autoclave and 0.5 g of ethyl 1-chloro-2-fluoro-1-cyclopropanecarboxylate (cis:trans=1.4:1), 0.5 ml of Raney nickel and 5 ml of ethanol were fed thereinto. Then 0.18 mg of 1,2-diaminoethane was further added and the mixture was stirred at room temperature under an elevated hydrogen gas atmosphere (10 kgf/cm2) for 48 hours. After the completion of the reaction, the catalyst was filtered off. Then the reaction mixture containing the title compound was analyzed by gas chromatography. As a result, it was found out that the reaction conversion rate was 95%, the yield was 81% and the cis:trans ratio was 0.3:1.

후처리

  1. customAfter the completion of the reaction
  2. filtrationthe catalyst was filtered off
  3. additionThen the reaction mixture containing the title compound

출처 및 근거

ORD 기록
ord-5656af2acacb4db4b1e2b0c10c97e9a2
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05780669

연결된 노트

불러오는 중…