Hydrochloric Acid → HCID 178508892, 화합물
반응식
C([O:3][C:4](=[O:35])[CH2:5][NH:6][S:7]([C:10]1[S:11][C:12]([CH2:15][CH2:16][CH:17]2[CH2:34][NH:33][C:20]3[N:21]=[C:22]([NH:26]C(=O)C(C)(C)C)[N:23]=[C:24]([OH:25])[C:19]=3[CH2:18]2)=[CH:13][CH:14]=1)(=[O:9])=[O:8])C.Cl>[OH-].[Na+]>[NH2:26][C:22]1[N:23]=[C:24]([OH:25])[C:19]2[CH2:18][CH:17]([CH2:16][CH2:15][C:12]3[S:11][C:10]([S:7]([NH:6][CH2:5][C:4]([OH:35])=[O:3])(=[O:8])=[O:9])=[CH:14][CH:13]=3)[CH2:34][NH:33][C:20]=2[N:21]=1참가 물질
4
실험 절차
A solution of 33 mg (0.062 mmol) of N-{5-[2-(2-pivaloylamino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)-ethyl]thien-2-ylsulfonyl}glycine ethyl ester in 3.0 mL of 1.0N sodium hydroxide was stirred at room temperature for 24 hours. The reaction mixture was then acidified with 1.0N hydrochloric acid and the white precipitate was collected by filtration to give 28 mg of N-{5-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)-ethyl]thien-2-ylsulfonyl}glycine.