Water → HCID 86752944, 화합물

HRID 1957579노트

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HRID 1957579 반응식
C[O:2][C:3](=[O:39])[C@@H:4]([NH:31][S:32]([CH2:35][CH2:36][CH2:37][CH3:38])(=[O:34])=[O:33])[CH2:5][NH:6][C:7]([C:9]1[O:13][N:12]=[C:11]([O:14][CH2:15][CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]2)[CH:10]=1)=[O:8].O[Li].O.O.OS([O-])(=O)=O.[Na+]>C1COCC1>[C:24]([N:21]1[CH2:20][CH2:19][CH:18]([CH2:17][CH2:16][CH2:15][O:14][C:11]2[CH:10]=[C:9]([C:7]([NH:6][CH2:5][C@H:4]([NH:31][S:32]([CH2:35][CH2:36][CH2:37][CH3:38])(=[O:34])=[O:33])[C:3]([OH:39])=[O:2])=[O:8])[O:13][N:12]=2)[CH2:23][CH2:22]1)([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25]

참가 물질

6

반응물 4

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 516919Sodium BisulfateHCID 86752943HCID 86752943, 화합물

생성물 1

HCID 86752944HCID 86752944, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 3-8 (1.86 mg, 0.32 mmol), LiOH.H2O (67 mg, 1.6 mmol), H2O (2 mL), and THF (8 mL) was stirred at ambient temperature for 1.0 h. The solution was acidified with 1M NaHSO4 followed by evaporation of THF. The residue was partitioned between EtOAc and brine. The EtOAc layer was then dried (MgSO4) and concentrated to give 3-9 as a pale yellow solid. Rf 0.40 (silica, 9/.0.5/0.5 CH2Cl2 :CH3OH:HOAc).

후처리

  1. customfollowed by evaporation of THF
  2. customThe residue was partitioned between EtOAc and brine
  3. dry with materialThe EtOAc layer was then dried (MgSO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-64da6f58d0bf45ea8ee01a8bf3c0e615
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05786373

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