Methyl iodide → HCID 58405900, 화합물

HRID 1957987노트

반응식

HRID 1957987 반응식
[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[CH2:6][N:5]([CH:13]([CH3:15])[CH3:14])[C:4]=2[N:3]=1.I[CH3:17].[H-].[Na+]>CC(N(C)C)=O>[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:17])[C:7](=[O:12])[CH2:6][N:5]([CH:13]([CH3:15])[CH3:14])[C:4]=2[N:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 592861702-chloro-8-isopropyl-7,8-dihydro-5H-pteridin-6-one

생성물 1

HCID 58405900HCID 58405900, 화합물수율 70%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

2-Chloro-8-isopropyl-7,8-dihydro-5H-pteridin-6-one (28 g; 0.118 mol) in Dimethylacetamide (100 ml) was cooled to −5° C. and iodomethane (8.839 ml; 0.141 mmol)) was quickly added. Then, NaH (7.1 g; 0.177 mmol) was added in portions. After 1 h the reaction mixture was allowed to reach room temperature and was maintained at that temperature until complete conversion of the starting material into the desired product. The reaction mixture was diluted with water and ice and the precipitate formed was filtered and dried in vacuo. 20 g (0.083 mol; 70% yield) of a white powder were obtained.

후처리

  1. customto reach room temperature

출처 및 근거

ORD 기록
ord-861c82b804234e21adb9b8d7e298b6b1
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410100B2

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