4-Chlorobenzonitrile → 4-Chlorobenzenehydroxamic acid

HRID 1963004

반응식

HRID 1963004 반응식
Cl[C:2]1[CH:9]=[CH:8][C:5]([C:6]#N)=[CH:4][CH:3]=1.[ClH:10].[NH2:11][OH:12].[OH-:13].[Na+]>CCO>[Cl:10][C:2]1[CH:9]=[CH:8][C:5]([C:6]([NH:11][OH:12])=[O:13])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 121634-ChlorobenzonitrileHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 5871784-Chlorobenzenehydroxamic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 4-chiorobenzonitrile (0.50 g, 3.60 mmol) in EtOH (10 ml) was added hydroxylamine hydrochloride (0.15 g, 3.60 mmol) and NaOH (2.90 g, 3.60 mmol). The resulting reaction mixture was refluxed for 2 h. After the completion of the reaction (TLC monitoring), the mixture was concentrated, added EtOH and filtered. The filtrate was evaporated in vacuo and used as such for the next step (crude yield 0.50 g, 77%).

후처리

  1. customThe resulting reaction mixture
  2. temperaturewas refluxed for 2 h
  3. customAfter the completion of the reaction (TLC monitoring)
  4. concentrationthe mixture was concentrated
  5. additionadded EtOH
  6. filtrationfiltered
  7. customThe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-4a59d33dd24d46bb9250f26d1ac3c8f6
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415383B2

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