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Hydrochloric Acid → 7-Bromo-2-(3-fluoro-2-methyl-benzyl)-3-phenyl-indolizine-1-carboxylic acid

HRID 1963097
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인쇄 미리보기

반응식

HRID 1963097 반응식
C[O:2][C:3]([C:5]1[C:6]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:23]=2[CH3:29])=[C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:8]2[C:13]=1[CH:12]=[C:11]([Br:14])[CH:10]=[CH:9]2)=[O:4].[OH-].[Na+].Cl>O1CCOCC1>[Br:14][C:11]1[CH:10]=[CH:9][N:8]2[C:13]([CH:12]=1)=[C:5]([C:3]([OH:4])=[O:2])[C:6]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:23]=1[CH3:29])=[C:7]2[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 706641557-Bromo-2-(3-fluoro-2-methyl-benzyl)-3-phenyl-indolizine-1-carboxylic acid methyl ester

생성물 1

HCID 677729597-Bromo-2-(3-fluoro-2-methyl-benzyl)-3-phenyl-indolizine-1-carboxylic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
90 °C

실험 절차

The compound of step 1 (450 mg, 0.99 mmol) was dissolved in 1,4-dioxane (10 ml) and treated with 10 ml of an aqueous 10 N solution of sodium hydroxide. The mixture was heated to 90° C. for 12 h, cooled to room temperature and neutralized with dilute hydrochloric acid. The aqueous phase was extracted with DCM, and the combined organic phase were dried over sodium sulfate. The crude title product obtained after evaporation was used without purification in the next step.

후처리

  1. extractionThe aqueous phase was extracted with DCM
  2. dry with materialthe combined organic phase were dried over sodium sulfate

출처 및 근거

ORD 기록
ord-662cf9e08e8f4a72b97ca9403685283e
출처 데이터셋
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08415336B2

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