Hydrochloric Acid → 3-hydroxy-N-methoxy-N-methylcyclobutanecarboxamide

HRID 1966164노트

반응식

HRID 1966164 반응식
[CH3:1][O:2][N:3]([CH3:11])[C:4]([CH:6]1[CH2:9][C:8](=[O:10])[CH2:7]1)=[O:5].CO.[BH4-].[Na+].Cl>>[OH:10][CH:8]1[CH2:9][CH:6]([C:4]([N:3]([O:2][CH3:1])[CH3:11])=[O:5])[CH2:7]1

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 4311764Sodium borohydrideHCID 86634348N-methoxy-N-methyl-3-oxocyclobutanecarboxamide

생성물 1

HCID 186915573-hydroxy-N-methoxy-N-methylcyclobutanecarboxamide수율 146.6%

실험 절차

N-Methoxy-N-methyl-3-oxocyclobutanecarboxamide (1 g, 0.006 mol) was dissolved in methanol (8 mL, 0.2 mol). To the mixture, sodium borohydride (0.2 g, 0.006 mol) was added. The reaction was stirred at rt for 1 h. To the reaction mixture was added 1N aq. HCl to adjust the pH to 2. The mixture was concentrated, then extracted with EtOAc. The combined organic layers were dried over MgSO4 and concentrated to give crude product (1.4 g) as light yellow oil. LCMS calculated for C7H14NO3(M+H)+: 160.0. Found: 160.3.

후처리

  1. concentrationThe mixture was concentrated
  2. extractionextracted with EtOAc
  3. dry with materialThe combined organic layers were dried over MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f6d69ab6914d48fd837fdeb5e79fe91b
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420629B2

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