Carbon tetrabromide → 2-(Bromomethyl)-5,8-dioxaspiro[3.4]octane
반응식
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH2:20]1[C:23]2([O:27][CH2:26][CH2:25][O:24]2)[CH2:22][CH:21]1[CH2:28]O.[Br:30]C(Br)(Br)Br>ClCCl>[Br:30][CH2:28][CH:21]1[CH2:22][C:23]2([O:27][CH2:26][CH2:25][O:24]2)[CH2:20]1참가 물질
5
실험 절차
Triphenylphosphine (6.28 gm, 24 mmol) in dichloromethane was added drop wise to a solution of 5,8-dioxaspiro[3.4]oct-2-ylmethanol (2.3 gm, 16 mmol) (step d) and tetrabromomethane (6.62 gm, 20 mmol) in dichloromethane. The reaction mixture was stirred at room temperature for about 6 hours. The solvent was removed under reduced pressure and the residue was extracted with diethyl ether. The organic layer was concentrated under reduced pressure to get a crude product, which was purified by column chromatography.
후처리
- customThe solvent was removed under reduced pressure
- extractionthe residue was extracted with diethyl ether
- concentrationThe organic layer was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-27b029d0d56d47e8b60325e2660a95c2
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08420666B2
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