Benzocaine → HCID 67128324, 화합물

HRID 1971764노트

반응식

HRID 1971764 반응식
[N:1]1([CH:6]([CH3:10])[C:7]([OH:9])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH2:35]([O:37][C:38](=[O:46])[C:39]1[CH:44]=[CH:43][C:42]([NH2:45])=[CH:41][CH:40]=1)[CH3:36].CCN(C(C)C)C(C)C>CN(C=O)C.O.C(#N)C>[N:1]1([CH:6]([CH3:10])[C:7]([NH:45][C:42]2[CH:41]=[CH:40][C:39]([C:38]([O:37][CH2:35][CH3:36])=[O:46])=[CH:44][CH:43]=2)=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

8

반응물 4

HCID 2337BenzocaineHCID 81531DiisopropylethylamineHCID 31571772-(Pyrrolidin-1-yl)propanoic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

생성물 1

HCID 67128324HCID 67128324, 화합물

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 6342Acetonitrile용매

실험 절차

To the 2-pyrrolidin-1-yl-propanoic acid (200 mg, 1.4 mmol) in DMF (10 mL), was added HATU (586 mg, 1.5 mmol), 4-amino-benzoic acid ethyl ester (231 mg, 1.4 mmol) and DIPEA (0.5 mL, 2.8 mmol). The reaction mixture was stirred at room temperature for 16 hours, diluted with water and acetonitrile, purified by preparative HPLC, and lyophilized to give ethyl 4-(2-(pyrrolidin-1-yl)propanamido)benzoate.

후처리

  1. custompurified by preparative HPLC

출처 및 근거

ORD 기록
ord-a1e643c6189241ddbd98d8663ae82d7f
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431610B2

반응 노트

불러오는 중…