Carbon tetrabromide → 4-(Bromomethyl)-2-methoxypyridine
반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][N:4]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:31]>C(Cl)Cl>[Br:31][CH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=1참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a 100-mL round-bottomed flask was added (2-methoxy-4-pyridinyl)methanol (1.52 g, 10.92 mmol), triphenylphosphine (3.15 g, 12.02 mmol, Aldrich, St. Louis, Mo.), and carbon tetrabromide (1.165 mL, 12.02 mmol, Aldrich, St. Louis, Mo.) in DCM (20 mL). The reaction mixture was stirred at 0° C. for 2 h. The solvent was removed in vacuo and the residue was purified by silica gel chromatography, eluting with 20% EtOAc/hexanes to give 4-(bromomethyl)-2-methoxypyridine (1.98 g) as a colorless oil.
후처리
- customThe solvent was removed in vacuo
- customthe residue was purified by silica gel chromatography
- washeluting with 20% EtOAc/hexanes
출처 및 근거
- ORD 기록
- ord-b0103361177645e7b7c8047be594a141
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08431563B2
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