Hydrochloric Acid → 2-(4-Methylphenyl)quinazolin-4(3H)-one

HRID 1973868노트

반응식

HRID 1973868 반응식
N1C=CC=CC=1.[OH-].[Na+].Cl.C(O)C.[CH3:13][C:14]1[CH:31]=[CH:30][C:17]([C:18]([NH:20][C:21]2[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=2[C:23]([NH2:25])=[O:24])=O)=[CH:16][CH:15]=1>>[CH3:13][C:14]1[CH:31]=[CH:30][C:17]([C:18]2[NH:25][C:23](=[O:24])[C:22]3[C:21](=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:20]=2)=[CH:16][CH:15]=1

참가 물질

6

반응물 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 1049PyridineHCID 14798Sodium HydroxideHCID 8196472-[(4-methylbenzoyl)amino]benzamide

생성물 1

HCID 1354521092-(4-Methylphenyl)quinazolin-4(3H)-one수율 93.1%

실험 절차

A mixture of 11 ml of pyridine in 340 ml of 2 normal aqueous sodium hydroxide was heated to the reflux temperature and to the hot solution was added in one portion 16.3 g of 2-(4-methylbenzamido)benzamide. The mixture was maintained at reflux temperature for 15 minutes, then poured into 1000 ml of ice. The cold mixture was acidified with concentrated hydrochloric acid and the precipitate was cooled to give 14.1 g of white 2-(4-methylphenyl)-quinazolin-4(3H)-one, m.p. 242°-243.5° (from ethanol).

후처리

  1. temperaturewas heated to the reflux temperature and to the hot solution
  2. temperatureThe mixture was maintained
  3. temperatureat reflux temperature for 15 minutes
  4. temperaturethe precipitate was cooled

출처 및 근거

ORD 기록
ord-f55a12b503544866bfe4d9cc4b9cd70a
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03998951

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