Sodium Hydroxide → 2-Methoxypyridin-4-amine

HRID 1974832

반응식

HRID 1974832 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][N+:4]=1[O-].[OH-].[Na+]>C(O)(=O)C.[Fe]>[NH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 5792072-Methoxy-4-nitropyridine-n-oxide

생성물 1

HCID 2808912-Methoxypyridin-4-amine

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

A mixture of 6.3 g of 2-methoxy-4-nitropyridine N-oxide and 12.6 g of iron powder in 150 ml of acetic acid is heated for 1 hour at 100° C. After cooling, sodium hydroxide is added, the mixture is then filtered and the material on the filter is washed with water. The aqueous phase is extracted with ethyl ether. After drying and concentration, 3.6 g of an oil are recovered which crystallizes to a white solid.

후처리

  1. temperatureAfter cooling
  2. filtrationthe mixture is then filtered
  3. washthe material on the filter is washed with water
  4. extractionThe aqueous phase is extracted with ethyl ether
  5. customAfter drying
  6. concentrationconcentration, 3.6 g of an oil
  7. customare recovered which
  8. customcrystallizes to a white solid

출처 및 근거

ORD 기록
ord-90187e1883424e1999df727823c3ea76
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05284838

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