Sodium Hydroxide → 2-Methoxypyridin-4-amine
반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][N+:4]=1[O-].[OH-].[Na+]>C(O)(=O)C.[Fe]>[NH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=1참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 6.3 g of 2-methoxy-4-nitropyridine N-oxide and 12.6 g of iron powder in 150 ml of acetic acid is heated for 1 hour at 100° C. After cooling, sodium hydroxide is added, the mixture is then filtered and the material on the filter is washed with water. The aqueous phase is extracted with ethyl ether. After drying and concentration, 3.6 g of an oil are recovered which crystallizes to a white solid.
후처리
- temperatureAfter cooling
- filtrationthe mixture is then filtered
- washthe material on the filter is washed with water
- extractionThe aqueous phase is extracted with ethyl ether
- customAfter drying
- concentrationconcentration, 3.6 g of an oil
- customare recovered which
- customcrystallizes to a white solid
출처 및 근거
- ORD 기록
- ord-90187e1883424e1999df727823c3ea76
- 출처 데이터셋
- uspto-grants-1994_02
- 특허 번호
- US05284838
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