Carbon tetrabromide → 1-(3,5-Dimethylphenoxy)-2-bromopropane

HRID 1975538

반응식

HRID 1975538 반응식
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:21].[CH3:25][CH:26](O)[CH2:27][O:28][C:29]1[CH:34]=[C:33]([CH3:35])[CH:32]=[C:31]([CH3:36])[CH:30]=1>C(Cl)Cl>[CH3:36][C:31]1[CH:30]=[C:29]([CH:34]=[C:33]([CH3:35])[CH:32]=1)[O:28][CH2:27][CH:26]([Br:21])[CH3:25]

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 110739942-Propanol, 1-(3,5-dimethylphenoxy)-

생성물 1

HCID 191002941-(3,5-Dimethylphenoxy)-2-bromopropane수율 74.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

0.94 Gram (3.6 mmol) of triphenylphosphine and 1.49 g (4.5 mmol) of carbon tetrabromide were added to a solution prepared by dissolving 0.54 g (3 mmol) of 1-methyl-2-(3,5-dimethylphenoxy)ethanol in 10 ml of methylene chloride, and the resultant mixture was stirred at room temperature for 30 minutes. After the reaction, the solid was separated by filtration, and the remaining methylene chloride solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=5:1 (v/v)) to give 0.54 g of 1-(3,5-dimethylphenoxy)-2-bromopropane (yield 74.7%).

후처리

  1. customprepared
  2. customAfter the reaction
  3. customthe solid was separated by filtration
  4. concentrationthe remaining methylene chloride solution was concentrated under reduced pressure
  5. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=5:1 (v/v))

출처 및 근거

ORD 기록
ord-619da100a3a84020af9a517059a1b0fc
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05286905

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