Hydrochloric Acid → 1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid
반응식
[I-].[CH3:2][N+:3]1[CH:8]=[CH:7][C:6]([C:9]([O:11]C)=[O:10])=[CH:5][CH:4]=1.[OH-:13].[Na+].Cl>O>[CH3:2][N:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][C:4]1=[O:13]참가 물질
5
반응 조건
- 온도
- 55 °C
실험 절차
A solution of N-methyl-4-methoxycarbonylpyridinium iodide (2.00 g, 7.16 mmol) in water (10 mL) at room temperature was treated sequentially with 14M sodium hydroxide (1.0 mL) and 1.8M K3Fe(CN)6 (1.5 mL), stirred for 4 hours, treated again with 1.8M K3Fe(CN)6 once per hour for 4 hours, heated at 55° C. for one hour, cooled to room temperature, and treated with 6M HCl to pH 3. The precipitate was collected, washed with ether and dried under vacuum to provide 1.00 g of the desired product.
후처리
- temperaturecooled to room temperature
- customThe precipitate was collected
- washwashed with ether
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-8c4da58f0dc249f5a86210fcb45b6efe
- 출처 데이터셋
- uspto-grants-2001_05
- 특허 번호
- US06228868B1
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