Trifluoroacetic acid → HCID 21997550, 화합물

HRID 1977305노트

반응식

HRID 1977305 반응식
[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.N[NH:16][C:17]([NH2:19])=[S:18].FC(F)(F)C(O)=O.[OH-].[Na+]>C1(C)C=CC=CC=1.O>[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]3[S:18][C:17]([NH2:19])=[N:16][N:12]=3)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

7

반응물 4

HCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 7667714-Piperidin-1-ylbenzonitrileHCID 2723789Thiosemicarbazide

생성물 1

HCID 21997550HCID 21997550, 화합물수율 85.4%

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

반응 조건

온도
60 °C

실험 절차

To a solution of 4-piperidin-1-yl-benzonitrile (3 g) and thiosemicarbazide (1.8 g) in toluene (30 ml) was added trifluoroacetic acid (20 ml) and the mixture was stirred at 60° C. for 6 hours. The reaction mixture was placed in water, the solution was adjusted to pH 9 with 1N sodium hydroxide and the precipitate was collected by filtration to give 5-(4-piperidin-1-yl-phenyl)-[1,3,4]thiadiazol-2-yl-amine (3.58 g).

후처리

  1. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-a70202f4891943988ec3e6648d1582fb
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06232290B1

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