Hydrochloric Acid → 1-Ethylcyclobutane-1-carboxylic acid

HRID 1977899

반응식

HRID 1977899 반응식
[CH:1]([N-]C(C)C)(C)[CH3:2].[Li+].[CH:9]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11][CH2:10]1.C(I)C.Cl>C1COCC1>[CH2:1]([C:9]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11][CH2:10]1)[CH3:2]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6340IodoethaneHCID 19494Cyclobutanecarboxylic acidHCID 2724682Lithium diisopropylamide

생성물 1

HCID 219960331-Ethylcyclobutane-1-carboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of lithium diisopropylamide (800 ml; 2.0 M THF solution) in THF (800 ml) was added dropwise over a period of 50 minutes under cooling with ice, a solution of cyclobutanecarboxylic acid (80 g) in THF (100 ml) and the mixture was stirred at room temperature for two hours. To the mixture ethyl iodide (64.0 ml) was added dropwise and the mixture was stirred at room temperature overnight. To the reaction solution was added 2N hydrochloric acid and the mixture was extracted with ethyl acetate. The organic layer was washed by water and a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give 1-ethylcyclobutanecarboxylic acid (142 g).

후처리

  1. temperatureunder cooling with ice
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed by water
  4. dry with materiala saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7ff6bf60966240309587475510ca53c3
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235780B1

연결된 노트

불러오는 중…