Water → 1-bromo-2-propoxybenzene
반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][CH2:17][CH3:18].O>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:16][CH2:17][CH3:18]참가 물질
6
실험 절차
In DMF (120 ml) was dissolved 2-bromophenol (12 g). To the mixture was added potassium carbonate (12.5 g) and then was added bromopropane (7.2 ml), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was added to water, and the mixture was extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column chromatography (hexane/ethyl acetate=12/1) to give 1-bromo-2-propoxybenzene (10.5 g).
후처리
- extractionthe mixture was extracted with ethyl acetate
- washwashed with saturated brine
- dry with materialdried with magnesium sulfate
- customUnder reduced pressure, the solvent was evaporated
- customthe residue was purified with silica gel column chromatography (hexane/ethyl acetate=12/1)
출처 및 근거
- ORD 기록
- ord-ded96d5b1a7c456db3da5e20a5cf4f09
- 출처 데이터셋
- uspto-grants-2001_05
- 특허 번호
- US06235771B1
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