Sodium Hydroxide → 4-(5-Fluoro-2-methoxyphenyl)piperidine

HRID 1978832노트

반응식

HRID 1978832 반응식
C([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[O:16][CH3:17])[CH2:5][CH2:4]1)=O.[OH-].[Na+]>Cl.CO>[F:15][C:13]1[CH:12]=[CH:11][C:10]([O:16][CH3:17])=[C:9]([CH:6]2[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]2)[CH:14]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 15512821HCID 15512821, 화합물2회

생성물 1

HCID 155128224-(5-Fluoro-2-methoxyphenyl)piperidine

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

실험 절차

The crude product of 1-formyl-4-(5-fluoro-2-methoxy-phenyl)-piperidine (0.80 g, 3.4 mmole) (Intermediate 3) was dissolved in HCl (16 mL, 0.5 N) and MeOH (5 mL), and the mixture was brought to reflux for 16 hours. The mixture was cooled to room temperature and basified with NaOH (2.5 N), and extracted with EtOAc (3×25 mL) to give 4-(5-fluoro-2-methoxy-phenyl)-piperidine which was used directly without further purification.

후처리

  1. temperatureto reflux for 16 hours
  2. extractionextracted with EtOAc (3×25 mL)

출처 및 근거

ORD 기록
ord-3fbb02d2f0d8464dbf66c1607c6496b9
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06239126B1

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