Hydrochloric Acid → alpha-Cyano-phenylacetic acid pentachlorophenylester

HRID 1980228

반응식

HRID 1980228 반응식
[C:1]([CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([OH:6])=[O:5])#[N:2].[Cl:13][C:14]1[C:19](O)=[C:18]([Cl:21])[C:17]([Cl:22])=[C:16]([Cl:23])[C:15]=1[Cl:24].O=P(Cl)(Cl)Cl.Cl>C(Cl)(Cl)(Cl)Cl>[Cl:13][C:14]1[C:19]([O:5][C:4](=[O:6])[CH:3]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:1]#[N:2])=[C:18]([Cl:21])[C:17]([Cl:22])=[C:16]([Cl:23])[C:15]=1[Cl:24]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 992PentachlorophenolHCID 24813Phosphorus oxychlorideHCID 26403alpha-Cyanobenzeneacetic acid

생성물 1

HCID 20402417alpha-Cyano-phenylacetic acid pentachlorophenylester

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

8 g. (0.05 moles) of α-cyanophenylacetic acid, 13 g. (0.05 moles) of pentachlorophenol are mixed together. 4.3 g. (0.05 moles) of phosphoroxychloride are added dropwise. The obtained mixture is heated slowly to 85°-90° C. on an oil-bath and the mixture is kept at this temperature until the HCl evolution ceases. When the reaction is completed, the mixture is cooled to room temperature, and the melt is taken up in 100 ml. of carbon tetrachloride. The solution is washed three times with 30 ml. of water, treated with decolorizing charcoal, dried and evaporated. The product is recrystalized from diisopropyl ether, and crystalline pentachlorophenyl ester is precipitated.

후처리

  1. temperatureThe obtained mixture is heated slowly to 85°-90° C. on an oil-bath
  2. washThe solution is washed three times with 30 ml
  3. additionof water, treated with decolorizing charcoal
  4. customdried
  5. customevaporated
  6. customThe product is recrystalized from diisopropyl ether, and crystalline pentachlorophenyl ester
  7. customis precipitated

출처 및 근거

ORD 기록
ord-18a9a5d6942141388dbe7abf23f673ab
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04508658

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