Hydrochloric Acid → 5-(4-Chlorophenylthio)pyrrole-3-carboxylic Acid
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[NH:13][CH:12]=[C:11]([C:14]([O:16]C)=[O:15])[CH:10]=2)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][C:9]2[NH:13][CH:12]=[C:11]([C:14]([OH:16])=[O:15])[CH:10]=2)=[CH:6][CH:7]=1참가 물질
5
실험 절차
Methyl 5-(4-chlorophenylthio)pyrrole-3-carboxylate (1.4 g.) was combined with 20 ml. of methanol and 20 ml. of 1N sodium hydroxide and heated on a steam bath for 2 hours. The reaction was cooled, acidified with conc. hydrochloric acid. and the crude product which precipitated, collected by filtration. Two recrystallizations from acetone/hexane afforded purified 5-(4-chlorophenylthio)pyrrole-3-carboxylic acid (740 mg., m.p. 171°-173° C.).
후처리
- temperatureThe reaction was cooled
- customand the crude product which precipitated
- filtrationcollected by filtration
- customTwo recrystallizations from acetone/hexane
- customafforded
- custompurified 5-(4-chlorophenylthio)pyrrole-3-carboxylic acid (740 mg., m.p. 171°-173° C.)
출처 및 근거
- ORD 기록
- ord-82ecab0a366a4ff4976e2e9f6b503c12
- 출처 데이터셋
- uspto-grants-1985_04
- 특허 번호
- US04511576
반응 노트
불러오는 중…