Water → 1,2-Dibenzyloxy-2-hydroxy-3,4-dichlorobenzene

HRID 1982264

반응식

HRID 1982264 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[C:4]([OH:9])[C:3]=1[OH:10].[H-].[Na+].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[OH2:21]>CN(C)C=O>[CH2:13]([O:9][CH:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[C:3]1([O:21][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[OH:10])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 198773,4-DichlorocatecholHCID 24758Sodium hydride

생성물 1

HCID 233177331,2-Dibenzyloxy-2-hydroxy-3,4-dichlorobenzene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In 250 ml of dimethylformamide is dissolved 8.95 g of the compound (II), and 4.80 g (2 equivalent) of 50% sodium hydride oily suspension and 10.25 g (1.3 equivalent) of benzyl bromide are added thereto. The mixture is stirred for 10 minutes under ice cooling, then poured into 200 ml of water, and sparingly soluble crystals are collected by filtration and recrystallized from hexane to give 2.096 g of 1,2-dibenzyloxy-2-hydroxy-3,4-dichlorobenzene, mp. 74°-75° C.

후처리

  1. additionare added
  2. filtrationare collected by filtration
  3. customrecrystallized from hexane

출처 및 근거

ORD 기록
ord-8e725f34052144fb81d94d40b125487e
출처 데이터셋
uspto-grants-1986_06
특허 번호
US04595767

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