4-Isopropylaniline → N-[4-(Propan-2-yl)phenyl]ethanimidic acid

HRID 1982742노트

반응식

HRID 1982742 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[CH:8]([C:11]1[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=1)([CH3:10])[CH3:9]>C(Cl)(Cl)Cl>[C:5]([NH:15][C:14]1[CH:16]=[CH:17][C:11]([CH:8]([CH3:10])[CH3:9])=[CH:12][CH:13]=1)(=[O:7])[CH3:6]

참가 물질

4

반응물 2

HCID 74644-IsopropylanilineHCID 7918Acetic Anhydride

생성물 1

HCID 258025N-[4-(Propan-2-yl)phenyl]ethanimidic acid

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Acetic anhydride (26.0 g, 254 mmol) is slowly added dropwise to a solution of 4-isopropylaniline (17.2 g, 127 mmol) in 80 ml of chloroform. In the course of this, intense heating of the reaction mixture occurs. On completion of the dropwise addition, the mixture is stirred at room temperature for another 2 h. The reaction mixture is concentrated to dryness and the resulting, reddish-white solid is recrystallized from hexane.

후처리

  1. temperatureIn the course of this, intense heating of the reaction mixture
  2. additionOn completion of the dropwise addition
  3. concentrationThe reaction mixture is concentrated to dryness
  4. customthe resulting, reddish-white solid is recrystallized from hexane

출처 및 근거

ORD 기록
ord-5971b1fea1034cda9ef8a0c487591110
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07540978B2

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