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Hydrochloric Acid → HCID 68867561, 화합물

HRID 1985175
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HRID 1985175 반응식
C[O:2][C:3](=[O:35])[C:4]([CH3:34])([CH3:33])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][CH:15]2[CH2:19][N:18]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=3)[C:17](=[O:31])[N:16]2[CH3:32])=[CH:8][CH:7]=1.[OH-].[Na+].Cl>CO>[CH3:33][C:4]([CH3:34])([CH2:5][C:6]1[CH:7]=[CH:8][C:9]([O:12][CH2:13][CH2:14][CH:15]2[CH2:19][N:18]([CH2:20][C:21]3[CH:22]=[CH:23][C:24]([C:27]([F:28])([F:30])[F:29])=[CH:25][CH:26]=3)[C:17](=[O:31])[N:16]2[CH3:32])=[CH:10][CH:11]=1)[C:3]([OH:35])=[O:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 688672152,2-Dimethyl-3-(4-{2-[3-methyl-2-oxo-1-(4-trifluoromethyl-benzyl)-imidazolidin-4-yl]-ethoxy}-phenyl)-propionic acid methyl ester

생성물 1

HCID 68867561HCID 68867561, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of the ester obtained from Step A (66 mg, 0.13 mmol) in methanol (1.5 ml) is added 5N NaOH (0.3 ml, 1.5 mmol), and the mixture stirred for 20 hours at ambient temperature. The mixture is poured into 1N HCl (20 ml), then extracted with ethyl acetate (2×15 ml). The combined ethyl acetate extracts were washed with water, brine, dried (Na2SO4), and concentrated to a foam (62 mg, 97%.

후처리

  1. extractionextracted with ethyl acetate (2×15 ml)
  2. washThe combined ethyl acetate extracts were washed with water, brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated to a foam (62 mg, 97%

출처 및 근거

ORD 기록
ord-b7519f8be31048a184821166f624407b
출처 데이터셋
uspto-grants-2009_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07544812B2

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