Sodium Hydroxide → 1-(4-1H-pyrazol-5-ylphenyl)-piperazine
반응식
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[NH:20][N:19]=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>Cl>[NH:20]1[C:16]([C:13]2[CH:12]=[CH:11][C:10]([N:7]3[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]3)=[CH:15][CH:14]=2)=[CH:17][CH:18]=[N:19]1참가 물질
4
실험 절차
To 5.1 g of 1-acetyl-4-(4-1H-pyrazol-5-ylphenyl)-piperazine, 60 ml of concentrated hydrochloric acid were added, followed by heating at reflux for 3 hours. After the completion of the reaction, the reaction solution was cooled and then neutralized with an aqueous 1N sodium hydroxide solution, thereby to precipitate a crystal. The resulting crystal was filtered, washed with a small amount of water and then dried to obtain 4.3 g of the objective 1-(4-1H-pyrazol-5-ylphenyl)-piperazine (melting point: 290° C. or higher).