N,N-Dimethylglycine → 1-methyl-5-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]phenyl}-2-pyrrolidinone

HRID 1988671노트

반응식

HRID 1988671 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([CH3:13])[C:11](=[O:14])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[F:15][C:16]([F:27])([F:26])[C:17]1[C:25]2[CH2:24][CH2:23][CH2:22][CH2:21][C:20]=2[NH:19][N:18]=1.CN(C)CC(O)=O.C(=O)([O-])[O-].[K+].[K+]>CS(C)=O.[Cu]I>[CH3:13][N:12]1[CH:8]([C:5]2[CH:6]=[CH:7][C:2]([N:19]3[C:20]4[CH2:21][CH2:22][CH2:23][CH2:24][C:25]=4[C:17]([C:16]([F:15])([F:27])[F:26])=[N:18]3)=[CH:3][CH:4]=2)[CH2:9][CH2:10][C:11]1=[O:14]

참가 물질

7

반응물 4

HCID 673N,N-DimethylglycineHCID 11430Potassium CarbonateHCID 28028633-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazoleHCID 577627945-(4-Bromophenyl)-1-methyl-2-pyrrolidinone

생성물 1

HCID 248259091-methyl-5-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]phenyl}-2-pyrrolidinone수율 7%

시약·촉매·용매 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 679Dimethyl Sulfoxide용매

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온도
180 °C

실험 절차

A mixture of 5-(4-bromophenyl)-1-methyl-2-pyrrolidinone (141 mg, 0.56 mmol), 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole (111 mg, 0.58 mmol), copper (I) iodide (10 mol %, 11 mg, 0.06 mmol), N,N-dimethylglycine (20 mol %, 12 mg, 0.12 mmol) and potassium carbonate (162 mg, 1.17 mmol) in dimethylsulfoxide (3 ml) was stirred at 180° C. in a microwave reactor for a total of 2 h. The reaction mix was filtered through a 5 g pre-packed silica column washing through with dichloromethane (20 ml), the filtrate was washed with water (50 ml) and the organic layer dried over sodium sulphate. The solvent was removed by rotary evaporation and the sample purified by mass directed auto prep. The final product was partitioned between dichloromethane (3 ml) and water (3 ml). The organic layer was separated and solvent removed by rotary evaporation to give the title compound as a brown oil (14 mg, 7%)

후처리

  1. additionThe reaction mix
  2. filtrationwas filtered through a 5 g pre-packed silica column
  3. washwashing through with dichloromethane (20 ml)
  4. washthe filtrate was washed with water (50 ml)
  5. dry with materialthe organic layer dried over sodium sulphate
  6. customThe solvent was removed by rotary evaporation
  7. customthe sample purified by mass
  8. customThe final product was partitioned between dichloromethane (3 ml) and water (3 ml)
  9. customThe organic layer was separated
  10. customsolvent removed by rotary evaporation

출처 및 근거

ORD 기록
ord-251e62f977f94400888713880efad631
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07642256B2

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