Methanol → 4-Amino-6-(1-methylcyclopropyl)-3-methylthio-1,2,4-triazin-5-one
반응식
[NH2:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2([CH3:12])[CH2:11][CH2:10]2)=[N:5][N:4]=[C:3]1[SH:13].[CH3:14]O.CI>[OH-].[Na+]>[NH2:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2([CH3:12])[CH2:10][CH2:11]2)=[N:5][N:4]=[C:3]1[S:13][CH3:14]참가 물질
5
실험 절차
198 g of compound obtained according to (b) is dissolved in 500 ml of 2 N NaOH, and 500 ml of methanol and 150 g of methyl iodide are added. The reaction mixture is stirred at 20° to 30° C. for 6 hours. The crystals which have formed are filtered off with suction, washed and dried to yield 174.5 g of final product (dried in vacuo at 40° C.); white crystals; melting point 115° to 116° C.; yield 82.3% of theory.
후처리
- customThe crystals which have formed
- filtrationare filtered off with suction
- washwashed
- customdried
출처 및 근거
- ORD 기록
- ord-43aaa1ef63c745ed8c05b41eef92b18e
- 출처 데이터셋
- uspto-grants-1983_09
- 특허 번호
- US04402733
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