Sulfuric Acid → 2-Chloro-5-phenylpyrazine

HRID 1995060

반응식

HRID 1995060 반응식
[C:1]1([C:7]2[N:8]=[CH:9][C:10](=O)[NH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O=P(Cl)(Cl)[Cl:16].S(=O)(=O)(O)O>>[Cl:16][C:10]1[CH:9]=[N:8][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:12][N:11]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 24813Phosphorus oxychlorideHCID 5990375-phenyl-1H-pyrazin-2-one

생성물 1

HCID 12366642-Chloro-5-phenylpyrazine

실험 절차

A mixture of 0.01 mol. of 5-phenylpyrazin-2(1H)one 8.0 ml. of POCl3 and a drop of concentrated sulfuric acid is refluxed for 4-5 hr. The solution is poured into 100 g. of ice. The title compound is isolated by filtration and recrystallized.

후처리

  1. additionA mixture of 0.01 mol
  2. additionThe solution is poured into 100 g

출처 및 근거

ORD 기록
ord-2130e3284caf45838b838060e626ad40
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04402958

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