Sodium Hydroxide → HCID 20402696, 화합물

HRID 1995096노트

반응식

HRID 1995096 반응식
[OH-:1].[Na+].Cl.[NH2:4]O.[C:6]([C:14]1[C:15]([NH:21][C:22](=[O:25])[CH2:23]I)=[CH:16][N:17]([CH3:20])[C:18]=1[CH3:19])(=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>O.C(O)C>[C:6]([C:14]1[C:15]([NH:21][C:22](=[O:25])[CH2:23][NH:4][OH:1])=[CH:16][N:17]([CH3:20])[C:18]=1[CH3:19])(=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 20402707HCID 20402707, 화합물

생성물 1

HCID 20402696HCID 20402696, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Sodium hydroxide (64 g) was added to a solution of hydroxylamine hydrochloride (111 g) in water (370 ml) and the obtained solution was diluted with ethanol (3500 ml). N-(4-benzoyl-1,5-dimethyl (1H)pyrrol-3-yl)-2-iodoacetamide (124.5 g) was then added and the obtained suspension was stirred under nitrogen stream for about 48 hours. The reaction mixture was filtered in order to remove the salts and the filtrate was concentrated to dryness at the pump. The residue was washed with a small amount of water and crystallized from ethyl acetate yielding 82.5 g of the compound of the title. M.p. 140°-42° C.

후처리

  1. filtrationThe reaction mixture was filtered in order
  2. customto remove the salts
  3. concentrationthe filtrate was concentrated to dryness at the pump
  4. washThe residue was washed with a small amount of water
  5. customcrystallized from ethyl acetate yielding 82.5 g of the compound of the title

출처 및 근거

ORD 기록
ord-db163fa095aa45ef80d432858154d889
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04402970

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