Sodium Hydroxide → 2-Hydroxy-6-nitroquinoline-3-carboxylic acid
반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[C:8]([C:15]([O:17]CC)=[O:16])=[CH:7]2)([O-:3])=[O:2].[OH-].[Na+]>Cl>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[C:8]([C:15]([OH:17])=[O:16])=[CH:7]2)([O-:3])=[O:2]참가 물질
4
실험 절차
A mixture of 9.7 g (37 mmol) of the above ester and 200 ml of 1 N sodium hydroxide is heated on the steam bath for 11/4 hours. The resulting suspension is poured over ice and acidified with 250 ml of 1 N hydrochloric acid. The solid is collected by filtration and washed with water and ethanol to give 8.15 g of the title acid, mp>310° C.
후처리
- temperatureis heated on the steam bath for 11/4 hours
- additionThe resulting suspension is poured over ice
- filtrationThe solid is collected by filtration
- washwashed with water and ethanol
출처 및 근거
- ORD 기록
- ord-95f565320e094a9fa727265b2fd66d75
- 출처 데이터셋
- uspto-grants-1983_09
- 특허 번호
- US04404201
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