Methane → 4-hydroxy-1H-1,2-benzisothiazole-1,1,3(2H)-trione
반응식
N[C:2]1[C:6]2[C:7]([OH:11])=[CH:8][CH:9]=[CH:10][C:5]=2[S:4](=[O:13])(=[O:12])[N:3]=1.[OH-:14].[Na+].C.Cl>O>[OH:11][C:7]1[C:6]2[C:2](=[O:14])[NH:3][S:4](=[O:13])(=[O:12])[C:5]=2[CH:10]=[CH:9][CH:8]=1참가 물질
6
실험 절차
5 gm (25.2 mmols) of 3-amino-4-hydroxy-1,2-benzoisothiazole-1,1-dioxide and 2.02 gm (50.5 mmols) of sodium hydroxide were refluxed in 15 ml of water for 6.5 hours. Subsequently, the solution was treated with activated charcoal at 60° C. and filtered. At 60° C. the filtrate was acidified with concentrated aqueous hydrochloric acid (about 5 ml, 0.06 mol). The resulting precipitate was filtered off, dried and recrystallized from water. 4.62 gm (92% of theory) of 4-hydroxy-1,2-benzoisothiazol-3(2H)-one-1,1-dioxide were obtained.
후처리
- filtrationfiltered
- customAt 60° C.
- filtrationThe resulting precipitate was filtered off
- customdried
- customrecrystallized from water
출처 및 근거
- ORD 기록
- ord-79c6259e31034bdcba1c8073e06a4e74
- 출처 데이터셋
- uspto-grants-1983_09
- 특허 번호
- US04404230
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