Carbon Monoxide → tert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

HRID 2001250

반응식

HRID 2001250 반응식
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:25][c:24]([c:11]2[CH2:10][CH2:9]1)[c:15]([O:16][CH2:17][c:18]3[cH:23][cH:22][cH:21][cH:20][cH:19]3)[cH:14][c:13](Br)[cH:12]2)=[O:7])([CH3:4])[CH3:3].[C-:26]#[O+:27].CC[SiH](CC)CC>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:25][c:24]([c:11]2[CH2:10][CH2:9]1)[c:15]([O:16][CH2:17][c:18]3[cH:23][cH:22][cH:21][cH:20][cH:19]3)[cH:14][c:13]([CH:26]=[O:27])[cH:12]2)=[O:7])([CH3:4])[CH3:3]

참가 물질

9

반응물 3

HCID 281Carbon MonoxideHCID 6327258TriethylsiliconHCID 132189892tert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

생성물 1

HCID 132190424tert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

시약·촉매·용매 5

HCID 81531Diisopropylethylamine시약HCID 167845palladium(II) acetate촉매HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)촉매HCID 6228Dimethylformamide용매HCID 117669-Phenylanthracene내부 표준

반응 조건

온도
80 °C

출처 및 근거

ORD 기록
ord-ce440f570dd949ae9e6a13a12c62a723
출처 데이터셋
39k HTE dataset from Pfizer
원본 링크
출처 보기

연결된 노트

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