7-Bromo-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,6-dione → 3,4-Dihydro-7-(4-methyl-1H-imidazol-1-yl)pyrido[2,1-c][1,4]oxazine-1,6-dione

HRID 2014616

반응식

HRID 2014616 반응식
[CH3:1][c:2]1[n:6][cH:5][nH:4][cH:3]1.Br[C:7]([C:17](=[O:18])[N:11]1[C:10]([C:15](=[O:16])[O:14][CH2:13][CH2:12]1)=[CH:9]2)=[CH:8]2>>[CH3:1][c:2]1[n:6][cH:5][n:4]([C:7]([C:17](=[O:18])[N:11]2[C:10]([C:15](=[O:16])[O:14][CH2:13][CH2:12]2)=[CH:9]3)=[CH:8]3)[cH:3]1

참가 물질

9

반응물 2

HCID 1224399027-Bromo-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,6-dioneHCID 178418800HCID 178418800, 화합물

생성물 1

HCID 683801743,4-Dihydro-7-(4-methyl-1H-imidazol-1-yl)pyrido[2,1-c][1,4]oxazine-1,6-dione

시약·촉매·용매 6

HCID 2724254Sodium bis(trimethylsilyl)amide시약HCID 167845palladium(II) acetate촉매HCID 11953610Di-tert-butyl[3,4,5,6-tetramethyl-2',4',6'-tris(propan-2-yl)-[1,1'-biphenyl]-2-yl]phosphane촉매HCID 1140Toluene용매HCID 312751,4-Dioxane용매HCID 117669-Phenylanthracene내부 표준

반응 조건

온도
100 °C

출처 및 근거

ORD 기록
ord-ca75a8412940423e8b9618fbd9ea9266
출처 데이터셋
39k HTE dataset from Pfizer
원본 링크
출처 보기

연결된 노트

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