Acetamide → Acetamidoglycolic acid

HRID 20187

반응식

HRID 20187 반응식
[C:1]([NH2:4])(=[O:3])[CH3:2].[C:5]([OH:9])(=[O:8])[CH:6]=[O:7]>CC(C)=O>[C:1]([NH:4][CH:6]([OH:7])[C:5]([OH:9])=[O:8])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 178AcetamideHCID 760Glyoxylic Acid

생성물 1

HCID 14212846Acetamidoglycolic acid

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of commercially available acetamide 34 and glyoxylic acid 41 was heated at reflux in acetone to give pure N-acetyl-2-hydroxyglycine 42 as a viscous yellow oil in quantitative yield. The 1H n.m.r. spectrum supported formation of the α-hydroxyglycine derivative 42 with the appearance of a methine (H2) doublet and broad amide (NH) doublet at δ 5.39 and δ 8.65 respectively. Spectroscopic data were in agreement with those reported in the literature.195

후처리

  1. temperaturewas heated

출처 및 근거

ORD 기록
ord-e76f8a57f7894eaca8797727c758d1d0
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745573B2

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