Glyoxylic Acid → Alpha-Hydroxyhippuric acid

HRID 20188

반응식

HRID 20188 반응식
[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([OH:14])(=[O:13])[CH:11]=[O:12]>CC(C)=O>[C:1]([NH:9][CH:11]([OH:12])[C:10]([OH:14])=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 760Glyoxylic AcidHCID 2331Benzamide

생성물 1

HCID 450272Alpha-Hydroxyhippuric acid

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of commercially available benzamide 35 and glyoxylic acid 41 was heated at reflux in acetone to give pure N-benzoyl-2-hydroxyglycine 65 as a colourless solid in quantitative yield (Scheme 4.12). The 1H n.m.r. spectrum supported formation of the ox-hydroxyglycine derivative 65 with the appearance of a methine (H2) doublet and broad amide (NH) doublet at δ 5.60 and δ 9.26 respectively. Spectroscopic data were in agreement with those reported in the literature.209

후처리

  1. temperaturewas heated

출처 및 근거

ORD 기록
ord-9b741076ad9544a8b379ce92eb9f70b0
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745573B2

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