(Difluoromethyl)trimethylsilane → tert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
반응식
C[Si]([CH:1]([F:3])[F:2])(C)C.[CH3:4][C:5]([O:8][C:9]([N:11]1[CH2:28][c:27]([c:14]2[CH2:13][CH2:12]1)[c:18]([O:19][CH2:20][c:21]3[cH:26][cH:25][cH:24][cH:23][cH:22]3)[cH:17][c:16](Br)[cH:15]2)=[O:10])([CH3:7])[CH3:6]>>[CH3:4][C:5]([O:8][C:9]([N:11]1[CH2:28][c:27]([c:14]2[CH2:13][CH2:12]1)[c:18]([O:19][CH2:20][c:21]3[cH:26][cH:25][cH:24][cH:23][cH:22]3)[cH:17][c:16]([CH:1]([F:3])[F:2])[cH:15]2)=[O:10])([CH3:7])[CH3:6]참가 물질
8
반응물 2
생성물 1
시약·촉매·용매 5
반응 조건
- 온도
- 80 °C
출처 및 근거
- ORD 기록
- ord-7707ab4aa13f4682869c8e84d1c10310
- 출처 데이터셋
- 39k HTE dataset from Pfizer
- 원본 링크
- 출처 보기
반응 노트
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