Hydrochloric Acid → 4-Benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid

HRID 2035549노트

반응식

HRID 2035549 반응식
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([N:20]([CH2:33][C:34]2[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=2)[C:21]2[CH:22]=[N:23][C:24]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[CH:25][CH:26]=2)=[CH:10][C:11]=1[NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:5])C.Cl>C(O)C.[OH-].[Na+].O>[CH2:13]([NH:12][C:11]1[CH:10]=[C:9]([N:20]([CH2:33][C:34]2[CH:35]=[CH:36][C:37]([O:40][CH3:41])=[CH:38][CH:39]=2)[C:21]2[CH:22]=[N:23][C:24]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[CH:25][CH:26]=2)[N:8]=[CH:7][C:6]=1[C:4]([OH:5])=[O:3])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 67411902HCID 67411902, 화합물

생성물 1

HCID 674139734-Benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid수율 119.4%

시약·촉매·용매 3

HCID 702Ethanol용매HCID 962Water용매HCID 14798Sodium Hydroxide용매

반응 조건

온도
80 °C

실험 절차

3.0 mg of 4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid ethylester was dissolved in 1 mL of ethanol, to which 1 mL of 2 mol/L sodium hydroxide in water was added, and stirred at 80° C. for 1 hour. After cooling, hydrochloric acid was added to neutralize the reaction mixture. It was extracted with chloroform, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated to obtain 3.4 mg of the title compound containing impurities as a brown oil. Without further purification, this was used in the next reaction as it was.

후처리

  1. additionwas added
  2. temperatureAfter cooling
  3. extractionIt was extracted with chloroform
  4. washthe extract was washed with saturated saline
  5. dry with materialdried on anhydrous sodium sulfate
  6. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-f7456403e9224c0db10419b49e71c533
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575153B2

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