Citric Acid → Aspirin potassium

HRID 2040495노트

반응식

HRID 2040495 반응식
[CH3:1][C:2]([O:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=1[C:11]([OH:13])=[O:12])=[O:3].C(=O)(O)[O-].C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C(=O)(O)[O-].[K+:35]>O>[C:2]([O:4][C:5]1[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:11]([O-:13])=[O:12])(=[O:3])[CH3:1].[K+:35]

참가 물질

6

반응물 4

HCID 311Citric AcidHCID 769Bicarbonate Ion5회HCID 2244Aspirin6회HCID 516893Potassium Bicarbonate

생성물 1

HCID 23676700Aspirin potassium

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The soluble aspirin composition of the present disclosure is formulated so that all aspirin is bound to particles of bicarbonate, i.e., the composition contains no non-agglomerated aspirin. The granules, containing aspirin, powdered heat-treated bicarbonate salt, resin and surfactant, are in mixture with crystalline particles of pharmaceutically-acceptable acid, such as citric acid, and crystalline particles of heat-treated bicarbonate salt, e.g., potassium bicarbonate. When the soluble aspirin composition is introduced to water or other aqueous medium, the pharmaceutically acceptable acid crystals and the heat-treated bicarbonate salt crystals strongly react with one another to effect effervescence and mixing of the composition in the liquid volume, and the pharmaceutically acceptable acid crystals react with the heat-treated bicarbonate salt in the granules to reactively break up and disperse the granules, with the reaction involving the aspirin in the granules, to yield potassium acetylsalicylate, which immediately dissolves in the aqueous medium without residue.

후처리

  1. additionmixing of the composition in the liquid volume
  2. additiondisperse the granules

출처 및 근거

ORD 기록
ord-ea1fe9dfe4e047fc9024ac3390ce7fe0
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580853B2

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