홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Hydroxide → 3-(1-phenylsulfonyl-4-hex-1-enyl-1H-pyrazol-3-yl)-pyridine

HRID 2043049
노트
인쇄 미리보기

반응식

HRID 2043049 반응식
[C:1]1([S:7]([N:10]2[CH:14]=[C:13]([CH:15]=[CH:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:12]([C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)=[N:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].NN.O>C(O)COCCO>[CH:15]([C:13]1[C:12]([C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)=[N:11][NH:10][CH:14]=1)=[CH:16][CH2:17][CH2:18][CH2:19][CH3:20].[C:1]1([S:7]([N:10]2[CH:14]=[C:13]([CH:15]=[CH:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:12]([C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)=[N:11]2)(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 672844273-(1-phenylsulfonyl-4-hex-1-enyl-1H-pyrazol-3-yl)-pyridine

생성물 2

HCID 672844273-(1-phenylsulfonyl-4-hex-1-enyl-1H-pyrazol-3-yl)-pyridineHCID 178442469HCID 178442469, 화합물

시약·촉매·용매 1

HCID 8117
Diethylene Glycol
용매

실험 절차

Compound 46A (0.34 g, 0.97 mmol), 0.7 g of KOH and 1 ml of NH2NH2.H2O were combined in diethylene glycol (10 ml) and warmed to reflux for 1 hour under N2. The mixture was cooled, concentrated and redissolved in MeOH. Filtration over 25 g of SCX-2 (MeOH followed by 1 N NH3/MeOH) and subsequent purification by flash chromatography (ethyl acetate) afforded 3-(4-hex-1-enyl-1H-pyrazol-3-yl)-pyridine (the deprotected analog of 46A). Yield 0.18 g (86%). (TLC diethyl ether Rf 0.18).

후처리

  1. temperaturewarmed
  2. temperatureto reflux for 1 hour under N2
  3. temperatureThe mixture was cooled
  4. concentrationconcentrated
  5. dissolutionredissolved in MeOH
  6. filtrationFiltration
  7. customover 25 g of SCX-2 (MeOH followed by 1 N NH3/MeOH) and subsequent purification by flash chromatography (ethyl acetate)

출처 및 근거

ORD 기록
ord-a5a1a08b385441688129934852204e93
출처 데이터셋
uspto-grants-2013_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08586606B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트