Hydrogen Bromide → 1-(3-Hydroxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone
반응식
C[O:2][C:3]1[CH:4]=[C:5]([C:9](=[O:17])[CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][N:12]2[CH3:16])[CH:6]=[CH:7][CH:8]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[C:5]([C:9](=[O:17])[CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][N:12]2[CH3:16])[CH:6]=[CH:7][CH:8]=1참가 물질
4
실험 절차
40.5 of 1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone are boiled under reflux for 6 hours with 180 ml of acetic acid and 180 ml of 47% hydrobromic acid. After concentration of the solution, the oily residue is brought to crystallization through treatment with 150 ml of hot ethanol. Cooling is allowed to take place, and 39.8 g (76% of theory) of the hydrobromide of the title compound is filtered off as greenish crystals: m.p. 165° to 168°.
후처리
- customAfter concentration of the solution, the oily residue is brought to crystallization through treatment with 150 ml of hot ethanol
- temperatureCooling
- filtrationis filtered off as greenish crystals
출처 및 근거
- ORD 기록
- ord-de4b1731d35c4d0a8b1e8f23c53058e2
- 출처 데이터셋
- uspto-grants-1980_04
- 특허 번호
- US04198424
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