Hydrogen Bromide → 1-(3-Hydroxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone

HRID 2049656

반응식

HRID 2049656 반응식
C[O:2][C:3]1[CH:4]=[C:5]([C:9](=[O:17])[CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][N:12]2[CH3:16])[CH:6]=[CH:7][CH:8]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[C:5]([C:9](=[O:17])[CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][N:12]2[CH3:16])[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 203441421-(3-Methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone

생성물 1

HCID 203441401-(3-Hydroxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

40.5 of 1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone are boiled under reflux for 6 hours with 180 ml of acetic acid and 180 ml of 47% hydrobromic acid. After concentration of the solution, the oily residue is brought to crystallization through treatment with 150 ml of hot ethanol. Cooling is allowed to take place, and 39.8 g (76% of theory) of the hydrobromide of the title compound is filtered off as greenish crystals: m.p. 165° to 168°.

후처리

  1. customAfter concentration of the solution, the oily residue is brought to crystallization through treatment with 150 ml of hot ethanol
  2. temperatureCooling
  3. filtrationis filtered off as greenish crystals

출처 및 근거

ORD 기록
ord-de4b1731d35c4d0a8b1e8f23c53058e2
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04198424

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