Hydrochloric Acid → HCID 20058734, 화합물

HRID 2050684노트

반응식

HRID 2050684 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:19]=[C:20]([OH:23])[C:21]=1[OH:22])[C:5]1[O:6][C:7]2[C:12]([C:13](=[O:18])[C:14]=1[C:15]([OH:17])=[O:16])=[CH:11][CH:10]=[CH:9][CH:8]=2.C(O[C:28](=[O:30])[CH3:29])(=O)C.Cl>N1C=CC=CC=1.ClCCl>[C:2]([O:23][C:20]1[CH:19]=[C:4]([CH:3]=[C:2]([O:1][C:28](=[O:30])[CH3:29])[C:21]=1[O:22][C:5](=[O:6])[CH3:4])[C:5]1[O:6][C:7]2[C:12]([C:13](=[O:18])[C:14]=1[C:15]([OH:17])=[O:16])=[CH:11][CH:10]=[CH:9][CH:8]=2)(=[O:1])[CH3:21]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 14304992HCID 14304992, 화합물

생성물 1

HCID 20058734HCID 20058734, 화합물

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6344Dichloromethane용매2회

실험 절차

3',4',5'-Trihydroxyflavone-3-carboxylic acid was dissolved in 4 ml absolute pyridine, and the solution was reacted with 0.57 ml acetic anhydride and stirred for two hours. Then it was worked up by diluting with 20 ml dichloromethane, pouring onto a mixture of dilute hydrochloric acid/ice water and shaking with dichloromethane. Here care must be taken that the aqueous phase remains acid (if necessary some dilute hydrochloric acid must be added). The dichloromethane phase was separated, washed with water, dried over sodium sulfate and evaporated. 0.8 g crude 3',4',5'-triacetoxyflavone-3-carboxylic acid were obtained which was immediately processed further without additional purification.

후처리

  1. additionmust be added)
  2. customThe dichloromethane phase was separated
  3. washwashed with water
  4. dry with materialdried over sodium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-2274da1c1763420cba9ff869a789f4a6
출처 데이터셋
uspto-grants-1991_05
특허 번호
US05013852

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