Hydrochloric Acid → 2-Methyl-4-methoxy-5-nitrophenol
반응식
S([O:5][C:6]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([O:15][CH3:16])=[CH:8][C:7]=1[CH3:17])(=O)(=O)C.[OH-].[Na+].Cl>CO.O>[CH3:17][C:7]1[CH:8]=[C:9]([O:15][CH3:16])[C:10]([N+:12]([O-:14])=[O:13])=[CH:11][C:6]=1[OH:5]참가 물질
6
실험 절차
In 110 ml of methanol was dissolved 15.5 g (59.4 mmol) of 2-methyl-4-methoxy-5-nitrophenyl mesylate. Then 6.5 g of sodium hydroxide dissolved in 20 ml of water was added thereto. The obtained mixture was heated under reflux for 1 hour. After cooling, concentrated hydrochloric acid was added to thereby acidify the mixture. Then 400 ml of water was added and crystals were precipitated. The crystals were collected by filtration and washed with water. Thus 10.9 g (59.4 mmol) of 2-methyl-4-methoxy-5-nitrophenol was obtained. The yield was 100%.
후처리
- additionwas added
- temperatureThe obtained mixture was heated
- temperatureunder reflux for 1 hour
- temperatureAfter cooling
- customcrystals were precipitated
- filtrationThe crystals were collected by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-f72d44e6a4f64d369075518aaaa7be56
- 출처 데이터셋
- uspto-grants-1991_05
- 특허 번호
- US05015260
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