Sodium Hydroxide → 6-Bromoimidazo[2,1-b][1,3]thiazole

HRID 2051112노트

반응식

Br.[NH:2]=[C:3]1[N:7]([CH2:8][C:9](O)=O)[CH:6]=[CH:5][S:4]1.P(Br)(Br)([Br:14])=O.[OH-].[Na+]>>[Br:14][C:9]1[N:2]=[C:3]2[N:7]([CH:8]=1)[CH:6]=[CH:5][S:4]2

참가 물질

반응물 3

HCID 14798Sodium Hydroxide

HCID 24613Phosphorus oxybromide

HCID 67866643HCID 67866643, 화합물

생성물 1

HCID 3299496-Bromoimidazo[2,1-b][1,3]thiazole

반응 조건

온도: 140 °C

실험 절차

A mixture of 10.0 g of 2-imino-4-thiazolin-3-yl-acetic acid hydrobromide and 30.0 g of phosphorus oxybromide is heated for 2 hours at 140° C. After cooling, the reaction mixture is poured into ice water, neutralized with 10% sodium hydroxide solution and filtered to collect the precipitated crystals. The crystals are recrystallized from toluene to afford the title compound of mp. 96°-98° C.

후처리

temperatureAfter cooling
filtrationfiltered
customto collect the precipitated crystals
customThe crystals are recrystallized from toluene

출처 및 근거

ORD 기록: ord-2369136b2bfa4f46bd4e240109c3e8f1
출처 데이터셋: uspto-grants-1991_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05017212

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