Sodium Hydroxide → 4,4,5,8-Tetramethyl-1-oxaspiro[2.5]octane

HRID 2051369

반응식

HRID 2051369 반응식
[OH-].[Na+].[CH3:3][C:4]1([CH3:13])[CH:9]([CH3:10])[CH2:8][CH2:7][CH:6]([CH3:11])[C:5]1=[O:12].[Cl-].[CH3:15][S+](C)C>CS(C)=O>[CH3:13][C:4]1([CH3:3])[CH:9]([CH3:10])[CH2:8][CH2:7][CH:6]([CH3:11])[C:5]21[O:12][CH2:15]2

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 51304442,2,3,6-TetramethylcyclohexanoneHCID 10176118Trimethylsulfonium chloride

생성물 1

HCID 187910594,4,5,8-Tetramethyl-1-oxaspiro[2.5]octane

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

According to a preferred embodiment of the invention, NaOH is added to a mixture consisting of 2,2,3,6-tetramethyl-1-cyclohexanone and trimethylsulfonium chloride in dimethylsulfoxide. The reaction is slightly exothermic, hence the necessity to maintain an external cooling of the reaction mixture so as to keep the temperature at about 25°-30° C. Good stirring is also applied for about 6 hr. 4,4,5,8-Tetramethyl-1-oxaspiro[2.5]octane is then obtained by extraction of the resulting mixture with petrol ether, concentration of the organic extracts and fractional distillation.

후처리

  1. additionis added to a mixture
  2. temperaturehence the necessity to maintain
  3. temperaturean external cooling of the reaction mixture so as
  4. customat about 25°-30° C

출처 및 근거

ORD 기록
ord-f85b611f44f54e56bd406f3464041f72
출처 데이터셋
uspto-grants-1991_05
특허 번호
US05017711

연결된 노트

불러오는 중…