Triethylamine → HCID 178523082, 화합물

HRID 2053800노트

반응식

HRID 2053800 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[C:22]([OH:24])=O)[C:5]([NH:7][CH2:8][C:9]1[NH:13][C:12]2[CH:14]=[CH:15][C:16]([Cl:18])=[CH:17][C:11]=2[N:10]=1)=[O:6].[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(CC)CC)C>CS(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[C:22]([N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:24])[C:5]([NH:7][CH2:8][C:9]1[NH:13][C:12]2[CH:14]=[CH:15][C:16]([Cl:18])=[CH:17][C:11]=2[N:10]=1)=[O:6]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 31268PyrrolidineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 178523088HCID 178523088, 화합물

생성물 1

HCID 178523082HCID 178523082, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Prepared analogously to Example 1d from 3-chloro-N-(5-chloro-1H-benzimidazol-2ylmethyl)-4-carboxybenzamide, pyrrolidine, TBTU, and triethylamine in DMSO at ambient temperature. HPLC-MS results: retention time: 3.43 minutes; C20H18Cl2N4O2 (417.29); mass spectrum: (M+H)+=417.2.

후처리

  1. customHPLC-MS results

출처 및 근거

ORD 기록
ord-d7c6df447ec046a18d878682332f69ce
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07326791B2

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