Chlorine → 4-(2-aminomethylpiperidin-1-ylcarbonyl)-3-chloro-N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]benzamide

HRID 2053970

반응식

HRID 2053970 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([C:11]([NH:13][CH:14]([C:16]2[NH:20][C:19]3[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:18]=3[N:17]=2)[CH3:15])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:26][CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]1.C(N(C(C)C)CC)(C)C.ClCl>CS(C)=O>[NH2:26][CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][N:29]1[C:4]([C:3]1[CH:7]=[CH:8][C:9]([C:11]([NH:13][CH:14]([C:16]2[NH:20][C:19]3[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:18]=3[N:17]=2)[CH3:15])=[O:12])=[CH:10][C:2]=1[Cl:1])=[O:6]

참가 물질

6

반응물 4

HCID 24526ChlorineHCID 81531DiisopropylethylamineHCID 90865Piperidine-2-methylamineHCID 178464831HCID 178464831, 화합물

생성물 1

HCID 1784648034-(2-aminomethylpiperidin-1-ylcarbonyl)-3-chloro-N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]benzamide

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Prepared analogously to Example 1d from rac.-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, rac.-2-aminomethylpiperidine, PFTU, and diisopropylethylamine in DMSO at ambient temperature. HPLC-MS results: retention time: 3.93 minutes; C23H25Cl2N5O2 (474.39); mass spectrum: (M−H)−=473/475/477 (chlorine isotope).

후처리

  1. customHPLC-MS results

출처 및 근거

ORD 기록
ord-81a814d9d9eb4667a1c3e87896e645a1
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07326791B2

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