2-(Dimethylamino)ethanol → HCID 69320189, 화합물

HRID 2055052노트

반응식

HRID 2055052 반응식
[C:1]([Si:5]([CH3:38])([CH3:37])[O:6][C:7]1[CH:8]=[CH:9][C:10]2[C:11]3[CH:24]([CH2:25][C:26]([OH:28])=[O:27])[O:23][C:22]4[CH:21]=[C:20]([O:29][Si:30]([C:33]([CH3:36])([CH3:35])[CH3:34])([CH3:32])[CH3:31])[CH:19]=[CH:18][C:17]=4[C:12]=3[CH2:13][O:14][C:15]=2[CH:16]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:39][N:40]([CH3:44])[CH2:41][CH2:42]O.CC(C)N=C=NC(C)C>CN(C1C=CN=CC=1)C.C(Cl)Cl>[CH3:39][N:40]([CH3:44])[CH2:41][CH2:42][O:27][C:26](=[O:28])[CH2:25][CH:24]1[C:11]2[C:10]3[CH:9]=[CH:8][C:7]([O:6][Si:5]([C:1]([CH3:2])([CH3:4])[CH3:3])([CH3:38])[CH3:37])=[CH:16][C:15]=3[O:14][CH2:13][C:12]=2[C:17]2[CH:18]=[CH:19][C:20]([O:29][Si:30]([C:33]([CH3:36])([CH3:35])[CH3:34])([CH3:31])[CH3:32])=[CH:21][C:22]=2[O:23]1

참가 물질

6

반응물 3

HCID 79022-(Dimethylamino)ethanolHCID 12734DiisopropylcarbodiimideHCID 21959303HCID 21959303, 화합물

생성물 1

HCID 69320189HCID 69320189, 화합물

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of [2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-yl]-acetic acid, the compound prepared as in Example 95 above, (56 mg, 0.1 mmol), 2-dimethylamino-ethanol (30 μL, 27 mg, 3.0 eq.), DIC (14 mg, 18 μL) and DMAP (12 mg) in DCM (2 mL) was stirred for 13 hours. The reaction mixture was then concentrated to yield [2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-yl]-acetic acid 2-dimethylamino-ethyl ester as a crude foam.

후처리

  1. concentrationThe reaction mixture was then concentrated

출처 및 근거

ORD 기록
ord-e206d64848144421be2fcd238fe90766
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07329654B2

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