Methanol → L-Tryptophan

HRID 2056789

반응식

HRID 2056789 반응식
[CH2:1]([N:11]=[C:12]=S)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]C.[CH3:14][OH:15].[OH2:16].C[N:18](C=O)C>>[NH2:18][C@H:9]([C:14]([OH:16])=[O:15])[CH2:8][C:7]1[C:6]2[C:1](=[CH:2][CH:3]=[CH:4][CH:5]=2)[NH:11][CH:12]=1

참가 물질

5

반응물 4

HCID 887MethanolHCID 962WaterHCID 6228DimethylformamideHCID 90535Decane, 1-isothiocyanato-

생성물 1

HCID 6305L-Tryptophan

실험 절차

To a suspension of compound AA (9.1 g) in dry N,N′-dimethylformamide (15 ml) was added n-decylisothiocyanate (1.2 ml). The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was poured on to Bondesil 40 μM C8 resin (400 g) that had been prewashed with methanol (1 L) and water (1 L). The product was eluted with methanol (800 ml) after being first washed with water (800 ml) followed by 20% acetonitrile in water (800 ml). Evaporation of the methanol gave compound BB as a yellow solid (7.3 g).

후처리

  1. washThe product was eluted with methanol (800 ml)
  2. washafter being first washed with water (800 ml)
  3. customEvaporation of the methanol

출처 및 근거

ORD 기록
ord-efc564ca20644543b396101ebb2cd497
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07335726B2

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