Hydrochloric Acid → 3-[4-(Trifluoromethyl)phenyl]but-2-enoic acid
반응식
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6](/[C:9](/[CH3:16])=[CH:10]/[C:11]([O:13]CC)=[O:12])=[CH:5][CH:4]=1.[OH-].[Na+].Cl>CCO.[Cl-].[Na+].O>[F:1][C:2]([F:17])([F:18])[C:3]1[CH:4]=[CH:5][C:6](/[C:9](/[CH3:16])=[CH:10]/[C:11]([OH:13])=[O:12])=[CH:7][CH:8]=1참가 물질
6
실험 절차
The product from Example 142A (3.5 g, 13.5 mmol) in EtOH (80 mL) was treated with aqueous 1M NaOH (40 mL) and stirred for 16 hours at ambient temperature. The reaction mixture was neutralized with 1N HCl (40 mL), diluted with brine, and extracted with diethyl ether to provide the title compound. NMR (CDCl3) 2.60 (s, 3H), 6.82 (s, 1H), 7.58 (d, 2H), 7.65 (d, 2H).
후처리
- extractionextracted with diethyl ether
출처 및 근거
- ORD 기록
- ord-02fb427ce50043b6b84f684f101d78fc
- 출처 데이터셋
- uspto-grants-2008_02
- 특허 번호
- US07335678B2
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